Crocodile shagreen is a rare eye condition that affects the cornea, the clear outer layer of the eye. It is characterized by the appearance of raised, opaque, grayish-white or yellowish-white nodules on the surface of the cornea. These nodules resemble the rough, scaly skin of a crocodile, hence the name “crocodile shagreen.”

The exact cause of crocodile shagreen is unknown, but it is believed to be a genetic condition. The condition is usually present at birth or develops in early childhood. Crocodile shagreen has been associated with several genetic disorders, including osteogenesis imperfecta, Marfan syndrome, and Ehlers-Danlos syndrome.

The most common symptom of crocodile shagreen is decreased vision, which may be present in one or both eyes. The nodules on the cornea can cause visual distortion and glare, making it difficult to see clearly. Some people with crocodile shagreen may also experience eye irritation, redness, and sensitivity to light.

Crocodile shagreen is typically diagnosed during a comprehensive eye exam. An eye doctor will examine the cornea using a slit lamp, a specialized microscope that allows them to visualize the surface of the eye in detail. Additional tests, such as corneal topography or optical coherence tomography (OCT), may also be performed to assess the thickness and integrity of the cornea.

There is no cure for crocodile shagreen, and treatment is focused on managing the symptoms. Treatment options may include:

  • Lubricating eye drops: Eye drops can help reduce dryness and discomfort associated with crocodile shagreen.
  • Corrective lenses: Prescription glasses or contact lenses may help improve vision by correcting refractive errors, such as nearsightedness or astigmatism.
  • Corneal transplant: In severe cases, a corneal transplant may be necessary to replace the damaged cornea with a healthy donor cornea.

The prognosis for crocodile shagreen varies depending on the severity of the condition and the associated symptoms. In some cases, the nodules on the cornea may become more prominent over time, leading to significant visual impairment. However, in many cases, the condition is stable and does not progress to the point of causing significant vision loss.

To summarize, Crocodile shagreen is a rare genetic condition that affects the cornea. It is characterized by the appearance of raised, opaque, grayish-white or yellowish-white nodules on the surface of the cornea. While there is no cure for crocodile shagreen, there are several treatment options available to manage the symptoms and improve vision. If you or a loved one has been diagnosed with crocodile shagreen, it is important to work closely with an eye doctor to develop an appropriate treatment plan and monitor the condition over time.

At The Eye Center- Dr. Mahnaz Naveed Shah & Associates our team of eight ophthalmology subspecialists/ eye specialists, eye surgeons who are considered amongst the very best eye specialists in Karachi and in Pakistan, have the diagnostic and treatment capabilities to treat from the simplest to the most complex patients. We work hard to provide our patients with the best possible medical and surgical eye care, in a state of the art purpose built eye care facility. We offer the entire array of medical, laser and surgical treatments to help provide patients the best possible care in the most efficient, safe and ethical manner.

If you need an appointment, please contact us at 03041119544 during our working hours or leave us a WhatsApp message at +923028291799 and someone will connect with you. Walk-in appointments are also available for emergencies. We can also be reached through our web portal on

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